CBS said the show's second season premiere episode will be shot in London in July. This will mark the first time the series, which imagines Sherlock as a brilliant sleuth and recovering drug addict, has been taped on location outside of New York.
Liu's Watson is a former surgeon and sober companion who assists Holmes in solving mysteries.
"We couldn't be more excited to have this opportunity to see Sherlock's old stomping grounds and take a closer look at a life that, until now, we've only been able to glimpse through the lens of his recovery," the show's executive producer and creator Robert Doherty said in a statement. "By meeting old friends and revisiting prior cases, Watson will gain even more insight into Holmes. She'll have to keep up with a Sherlock who is both more comfortable in his surroundings and even bolder in testing the limits of those around him."