Groening's comments came Saturday night during the University of California Los Angeles' annual entertainment symposium, The Hollywood Reporter said.
"It took us four years [to make] and it killed us," Groening said of "The Simpsons Movie."
The movie "stole animators from the show," Groening said, adding that despite bringing in $500 million, it drained other resources.
Another "Simpsons" movie will come in "Maybe another 10, 15 years," added longtime "Simpsons" producer-director David Silverman.
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