Combining sketches, short films, live comedy, field pieces and in-studio guest interviews, Holmes' as-yet-untitled, half-hour show is to premiere in the fall. It will air four nights a week at midnight, following "Conan," the cable network said.
"Pete Holmes is an enormously likable performer with an agile and innovative mind," executive producer Conan O'Brien said in a statement Tuesday. "I'm really looking forward to his show, and I've already had my son program my DVR."
"Pete is a phenomenal talent with a truly unique point of view," said Michael Wright, president and head of programming for TBS, TNT and Turner Classic Movies. "He has just the right comic sensibility and style we're looking for to follow 'Conan' in our late-night lineup."
"The first half of my meeting with Conan was spent making sure this wasn't all part of a new TBS prank show called 'You Got Coned!' The second half was spent expressing my sincerest enthusiasm and gratitude for this incredible dream come true," said Holmes.
Celebrity Families of 2014 [PHOTOS]