Manzo said Saturday that she and her husband, Tommy, had been separated since October, The (Newark, N.J.) Star-Ledger reported.
"My heart hurts but Tommy & I will always share a very special love," she tweeted. She also says she's grateful for the support of her her loved ones, "especially my spiritual friends. You know who u are xoxo."
The couple has one child, Lexi.
Dina Manzo left "Real Housewives" midway through the second season, and has since started working on an HGTV gardening show.