The presentation, scheduled for March 23, will honor films, music, sports and television shows chosen in a vote by fans.
Duhamel is the star of "Transformers: Dark of the Moon," "New Year's Eve" and "Safe Haven." He is married to pop star Fergie.
"Josh has come out to play before for Kids' Choice and as a previous 'best arm fart' winner we know he'll do what it takes to be a great host," Marjorie Cohn, president of content development for Nickelodeon and executive producer of the Kids' Choice Awards, said in a statement. "We promise that this year will deliver the special, one-of-a-kind surprise-filled slime-fest for which our annual telecast is famous."
"Nickelodeon's Kids' Choice Awards is a great event that celebrates kids by honoring their opinions and taps into the kid in all of us," said Duhamel. "I have a lot of secret plans for when I host the awards, but I can tell you I'm excited to lead millions of kids into total crazy fun, chaos ... and, of course, endless slime."