Shriner has played attorney Scotty Baldwin off and on since the 1970s.
He will return to the daytime drama in the footsteps of other veteran castmates Finola Hughes, Robin Mattson, Ian Buchanan, Tristan Rogers and Lynn Herring. Soap icon Genie Francis is to return next month, as well.
TVGuide.com said Shriner is headed back to Port Charles Feb. 19.
"I really wanted to go back and be part of all that fun," Shriner told the television news website.
"[Head writer] Ron Carlivati has gone on record saying he's been watching 'GH' since the Scotty and Laura days in the '70s, and you can tell he really loves bringing back that old history."
"General Hospital" is ABC's last soap opera after the cancellation of "All My Children" and "One Life to Live."