The show, which will mark its 48th year anniversary in November, celebrates the broadcast of its 12,000th episode Friday.
The renewal was announced Wednesday by Jennifer Salke, president of NBC Entertainment.
"We are thrilled to announce that 'Days of Our Lives' is not going anywhere. It is NBC's longest-running drama series by far and is one of the most historic brands in television," said Salke in a statement. "We commend [executive producer] Ken Corday and the entire creative team on continuing to keep the stories and characters fresh, exciting and relevant year after year."
"'Days of Our Lives' has maintained a loyal and dedicated fan base for more than four decades and continues to reach a new generation of viewers," said Steve Mosko, president of Sony Pictures Television. "We appreciate NBC's support over the years and, as the show celebrates this significant milestone, we are thrilled that the show will continue to be a part of the NBC family."
The announcement is more good news for soap opera fans. Earlier this week, producers said the canceled-in-2011 daytime dramas "One Life to Live" and "All My Children" are being revived online.