The women will appear in one of Go Daddy's two 30-second Super Bowl ads during the Super Bowl in New Orleans on Feb. 3, Go Daddy announced in Scottsdale, Ariz., Friday.
The commercial's title is "Perfect Match."
The event will mark Refaeli's first-ever Super Bowl commercial. The Israeli native ranks No. 1 on the 2012 Maxim Hot 100 list.
The commercial with be Patrick's 12th Go Daddy Super Bowl commercial -- more than any celebrity's in TV history, Go Daddy said.
Both women have modeled in the Sports Illustrated Swimsuit Edition, understand the power of the Internet and have built strong brands using the Web, Go Daddy said.
Refaeli said, "The opportunity to be in a Super Bowl commercial is thrilling ... and to partner with Go Daddy is something I just couldn't resist.I feel like the 'Perfect Match' commercial is a chance to be in an iconic Super Bowl spot that not only leaves people talking, but shows everyone what Go Daddy is really about. I really look forward to meeting Danica, too."
"Go Daddy attracts a lot of marketing attention. What really makes Go Daddy special, though, is the way they 'get it done' for their customers -- their brand of personalized service is unlike anything in the tech industry ... the commercials are just the icing on the cake and I think 'Perfect Match' will be one of those ads people rewind to see over and over," said Patrick.