The series, which won five Daytime Emmy Awards last season, has played at 3 p.m. ET weekdays for decades.
As of Sept. 10, it will be broadcast at 2 p.m. ET since Katie Couric's new syndicated daytime talk show is expected to air in the 3 p.m. time-slot in numerous markets.
"General Hospital" will celebrate its golden anniversary April 1, 2013.
"Approaching 50 historic years on ABC, 'General Hospital' is the longest-running American soap opera currently in production and the third longest-running drama in American television history," the network said in a news release Tuesday.