The program is to be taped Aug. 4 and will air Aug. 12, the cable network said.
"Although Roseanne appears to be a demure, soft-spoken woman eternally committed to the status quo, we believe under the surface is an explosive, trail-blazing cultural revolution. We are honored to roast her," Kent Alterman, the network's head of original programming and production, said in a statement Monday.
"Celebrating Roseanne's unprecedented achievements in comedy and television will surely inspire us to make this roast more reminiscent of the classic roasts, where the intimacy of friends jousting with each other came through."
"All I can say is good luck finding anything about me to make fun of... I mean, I've never made a mistake or offended anyone in my life," Roseanne said.