The show is to debut July 11 after the premiere of the fifth and final season of Glenn Close's "Damages," which moved to the satellite network from FX.
Sevigny, 37, will play the central character of Mia in "Hit and Miss," which is written and produced by Paul Abbott, creator of "Shameless" and "State of Play." Sevigny is best known for her roles in the HBO series "Big Love" and the films "Kids," "Boys Don't Cry" and "Shattered Glass."
"Mia's life is sent into a tailspin when she receives a letter from an ex-girlfriend dying from cancer revealing that Mia fathered a son 11 years ago," a synopsis said. "Faced with a difficult decision, Mia becomes the guardian to a new family, forcing her to mix her killer instincts with her newly developing maternal instincts. 'Hit and Miss' tells the story of a lethal killer at the heart of a troubled family and how all of their lives will be dramatically changed forever."