The CBS show will follow Holmes and Watson as they solve crimes in modern-day New York.
The first name of Liu's character, whom British Victorian-era author Arthur Conan Doyle initially created as a man, has not been reported.
"Sherlock," a series starring Benedict Cumberbatch and Martin Freeman as contemporary London sleuths Holmes and Watson, has been a huge hit in the United Kingdom on the BBC and in the United States on PBS. A third season is in production.
Liu is best known for her work on TV's "Ally McBeal" and "Southland," as well as the "Charlie's Angels" movies.