The Oscars for excellence in film for 2011 are to be handed out Feb. 26.
Winfrey, who will also appear at the 84th Academy Awards show, is the recipient of the academy's Jean Hersholt Humanitarian Award for her inspiring philanthropic efforts that have brought credit to the industry.
This year marks Kimmel's seventh consecutive Oscar special. The 2012 edition is expected to include appearances by Meryl Streep, George Clooney, Tom Hanks, Martin Scorsese, Helen Mirren, Charlize Theron, Don Cheadle, John Krasinski, Emily Blunt, Samuel L. Jackson and Cameron Diaz.
Academy Awards host Billy Crystal also will join Kimmel to kick off his post-Oscar show, while British rock band Coldplay will end the night with a Hollywood block-party performance on "JKL's" outdoor stage, ABC said.