"Shatner's World: We Just Live In It" is set for a limited engagement at the Music Box Theatre from Feb. 14 to March 4.
The 2-hour show will cover Shatner's life and career from Shakespearean stage actor to internationally known television icon, best known for his roles in "Star Trek," "T.J. Hooker" and "Boston Legal."
"I've been pretty busy since I last played the Music Box," Shatner said in a statement.
"I've been refurbished; I hope the theater has been, too. My plan has always been to return to Broadway every 50 years. I can't ask my fans to wait for me longer than Halley's Comet, so I'm coming back."
Shatner last appeared on Broadway in 1962 in "A Shot in the Dark." His other New York stage credits include "The World of Suzie Wong" and "Tamburlaine the Great."