Clarke, 22, beat out finalists Ben "Coach" Wade and Albert Destrade for the honor.
"I had my finger on the pulse and tried to figure out people's motivations and work within the framework of the game," UsMagazine.com quoted Clarke as saying after she won the reality competition series.
Clarke told People.com Monday she already knows what she'll do with the prize money.
"I'm in medical school, so I have a lot of bills to pay. I opened up the mini-bar this morning [at my hotel] and bought a very expensive Diet Coke, so I'm well on my way to the land of extravagance," the winner of the 23rd season of "Survivor" said.