The announcement was made Tuesday by the awards show's executive producer and director Jeff Margolis. SAG is honoring Moore for her career achievement and humanitarian accomplishments.
The 18th annual Screen Actors Guild Awards is to air Jan. 29 on TNT and TBS.
Moore and Van Dyke played suburban couple Rob and Laura Petrie from 1961 to 1966 in Van Dyke's eponymous sitcom based on the experiences of comedy writer Carl Reiner. In 1969, Van Dyke and Moore reunited for a one-hour variety special called "Dick Van Dyke and the Other Woman." They collaborated again in a 1979 episode of "The Mary Tyler Moore Hour," reprising their roles as the Petries in a comedic sketch, and co-starred in a PBS version of D.L. Coburn's Pulitzer Prize-winning stage play "The Gin Game" in 2002.
The two reunited one more time in 2004 for "The Dick Van Dyke Show Revisited," written by Reiner and starring other surviving members of the original show's cast.
Nominees for this year's SAG Awards are to be announced Wednesday in Los Angeles.