Police said a pickup truck crossed the median and struck the car Case and his wife Angela were in Tuesday afternoon, WVTM-TV, Birmingham, reported.
Angela Case has also worked at CNN as a writer for more than 20 years. She was hospitalized with undisclosed injuries, CNN said.
Stanley Wright Case was praised in a statement by Jim Walton, president of CNN Worldwide.
"Stan was a news anchor for CNN Radio and a mainstay of the network since he joined CNN in 1985," Walton said. "He was a fine journalist, a leader in our organization and, as anyone who had the privilege of knowing him will tell you, a great guy."
Case was a lawyer but chose to work in radio. He joined CNN in Atlanta after working as a correspondent for KEBC-AM in Oklahoma City.
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