"Oprah's Next Chapter" features the talk-show queen on the road to interview various celebrities in their natural habitat.
"After 25 years, I got myself out of the studio chairs," Winfrey said in a statement. "I moved into the next chapter, and I am having more fun than ever -- moving around the country and the world talking to people I'm really interested in getting to know and I think viewers will be, too."
The front-line role in the new series comes at a potentially pivotal time for OWN. The Los Angeles Times said Saturday that holding on to viewers has been a challenge for the network. OWN is also losing co-owner Peter Liguori at the end of the year, and Gayle King, Oprah's longtime pal, is defecting to CBS' "The Early Show."