Reubens is being recognized for creating the iconic film, TV and stage character Pee-wee Herman.
The program is to air Tuesday on Spike TV, with a simulcast on VH1 and VH1 Classic.
"If Pee-wee were giving this quote, I think he'd scream out: 'I'm a visionary! I'm a visionary!' and then run to the dictionary to look up what 'visionary' means. But I know what it means, and I am profoundly grateful and honored to Spike TV for this recognition. I share this with all the amazing collaborators I've had over the years and my fans, without whom none of this would be possible or worth it," Reubens said in a statement Thursday.
"Paul Reubens had a big vision and in bringing Pee-wee Herman and his amazing Playhouse to life, he brilliantly brought us all along on a very big adventure," said Michael Levitt, executive producer of Spike TV's SCREAM Awards 2011. "Pee-wee speaks to the inner child in all of us, with a grown-up wit and a timeless irreverence. At the Scream Awards, we honor a wide range of visionary geniuses and it has been a longstanding dream to have this chance to honor Paul -- and Pee-wee -- with the Scream Visionary Award."