Izzard starred on TV's "The Riches." His film credits include "Ocean's 12" and "Valkyrie."
He will appear in the Oct. 2 episode of "Wife" called "The Death Zone."
"When Alicia wins a verdict in a libel case involving a British businessman, she must quickly learn to navigate English Law when the case is retried in British court via satellite," CBS said in a synopsis. "Eddie Izzard guest stars as Queen's Council James Thrush."
Julianna Margulies plays Alicia.
Putin thinks Obama would save him if he were drowning
The Giudices celebrate Easter as they prepare for jail