Izzard starred on TV's "The Riches." His film credits include "Ocean's 12" and "Valkyrie."
He will appear in the Oct. 2 episode of "Wife" called "The Death Zone."
"When Alicia wins a verdict in a libel case involving a British businessman, she must quickly learn to navigate English Law when the case is retried in British court via satellite," CBS said in a synopsis. "Eddie Izzard guest stars as Queen's Council James Thrush."
Julianna Margulies plays Alicia.