Timberlake is being recognized at Saturday's event for his outstanding charitable and environmental efforts, the cable network said.
Jack Black will serve as host of the awards show at USC's Galen Center.
"Justin's ability to seamlessly incorporate helping into his life embodies the true spirit of the Big Help," Marva Smalls, executive vice president of public affairs and chief of staff at Nickelodeon/MTVN Kids and Family Group, said in a statement this week. "In true Big Help fashion, he combined his passion for helping kids with his love of golf and through his annual golf open benefit for Shriners Hospitals for Children, came up with a way for people to have fun while helping kids get medical care."
"I was inspired at a young age by my parents and family to do everything possible to give back to the world around us," added Timberlake. "And it has become a mission of mine to help kids of all ages understand the importance of getting involved in their communities and local charities and doing their part to preserve the planet. I couldn't be more thankful to Nickelodeon for their recognition."