Pearson, who played Snoop on the Baltimore-set series, was one of more than 30 people nabbed Thursday morning in the large-scale heroin and marijuana operation, The Baltimore Sun reported.
The 30-year-old actress, rapper and author was previously convicted when she was 14 of second-degree murder. She recently was arrested for refusing to testify as a witness at a murder trial, the newspaper said.
The Hollywood Reporter said David Simon, creator of "The Wire," issued a statement to Slate, reminding people Pearson is "entitled to the presumption of innocence."
"This young lady has, from her earliest moments, had one of the hardest lives imaginable. And whatever good fortune came from her role in 'The Wire' seems, in retrospect, limited to that project," Simon said. "She worked hard as an actor and was entirely professional, but the entertainment industry as a whole does not offer a great many roles for those who can portray people from the other America. There are, in fact, relatively few stories told about the other America."