Sheen, who has long battled an addiction to drugs, has raised eyebrows for his outrageous remarks during the past two weeks. During one rant, he called Cryer, his former "Two and a Half Men" co-star, a "troll" because, he claimed, Cryer hadn't reached out to him after he was fired from the show for his erratic behavior.
Cryer has not publicly commented on Sheen's dismissal or the fact that Sheen's behavior prompted the sitcom's producers to shelve the remainder of this season. It is unclear whether the show will return next season.
Cryer last week joked on "The Ellen DeGeneres Show" about working as a temp in her office because he needs the job.
When he appeared on "Conan" Thursday night, E! News said Cryer quipped, "The fact is, I am a troll."
"It's not something I like to talk about. My parents don't even know," Cryer said. "It turns out there's not a lot of tolerance for people like me, especially in Hollywood. You don't know how much time and money I've spent on electrolysis and hair dye and reconstructive surgery so that I can look like this."
E! News said Cryer named some of Hollywood's other trolls, including Paul Giamatti, Helen Mirren and Conan O'Brien's sidekick, Andy Richter.
"You son of a bitch," Richter quipped as he was "outed."