The as-yet-untitled show will follow Barr as she takes on her newest endeavor, running her 40-acre macadamia and livestock farm on Hawaii's Big Island alongside her longtime writer-musician boyfriend, Johnny Argent, and son, Jake.
The announcement was made Monday by Nancy Dubuc, Lifetime Networks' president and general manager.
The series will premiere on Lifetime this year, the network said.
"Roseanne Barr is an undeniable force of nature and the idea of following her in this unique premise excited us from the get-go," Dubuc said in a statement. "Roseanne is funny and brutally honest, and our audience will relate to her decision to go on this adventure and create an entirely new life for herself. We are thrilled she will make her long-awaited return to television on Lifetime."
"I'm coming back down to earth, and keeping it real," Barr added. "They've said 'Roseanne's nuts' for years, and now I'm going to make that a reality -- I'm all about nuts now, macadamia nuts!"
Barr created and starred in the classic sitcom "Roseanne."