Combs's appearance is to air this spring.
In it, he will play New York Police Department Detective Reggie Williams, "who hunts the streets of Honolulu for the men responsible for a crime against his family, but his one-man war for justice sets this fellow cop on a collision course with Five-0," the network said in a synopsis.
To prepare for his first action role, Combs will undergo weapons instruction and training with a Navy SEAL, CBS added.
Several of his biggest hit songs will also be featured throughout the episode.
Combs's other acting credits include roles in the films "Get Him to the Greek" and "Monster's Ball," and the play "A Raisin in the Sun."
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