The announcement was made Friday by Showtime Networks President of Entertainment David Nevins.
Twelve new episodes of the show are to go into production this spring. Season 4 began airing last week.
The cable network did not say when the fifth season would premiere.
"'Californication's' fourth season premiere delivered its best-ever premiere with over 1 million total viewers for the night. The series follows the exploits of writer Hank Moody as he works to balance his career, ex-girlfriend, daughter and hedonistic vices," Showtime said in a news release. "This season, Hank enlists the help of high-powered defense attorney Abby (guest star Carla Gugino) to keep him out of prison after he's charged with bedding a then-underage Mia (guest star Madeline Zima.) Fourth season guest stars include Rob Lowe, Zoe Kravitz, Stephen Tobolowsky and rocker Tommy Lee will make a cameo, as well."