Caitlin Burke, a 26-year-old New Yorker, won more than $53,000 and a trip to the Caribbean after guessing the answer was "I've got a good feeling about this" with only one letter showing.
Longtime host Pat Sajak described the accomplishment as "the most amazing solve we've ever had."
The show was taped in September and aired last Friday.
Burke told the New York Post competing on the show has been "No. 1 on my bucket list."
"Now that it's crossed off, I still need to fly in a helicopter and meet Eminem," she quipped.
Asked what she plans to do with the cash, Burke told the newspaper, "I am going to pay off my student loans, buy a Chanel bag and start my own business."