The couple have one child together.
"George and Ann Lopez have made the decision to end their 17-year marriage," Lopez's representative told People.com. "The decision is amicable and by mutual agreement. ... They remain dedicated parents, and committed partners in business and their philanthropic organization, The Lopez Foundation."
Lopez is the host of TBS's "Lopez Tonight."
Selena Gomez drops F-bomb, walks off stage during Jingle Ball performance
Exploding whale video goes viral on Internet