The episode is to air Sept. 22.
"Host Craig Ferguson will kick off the themed night with a taped sketch from the set of TV's No. 1 scripted series among (people ages) 18-49," the network said in a news release Thursday. "Then, the cast of 'The Big Bang Theory' will appear on Ferguson's stage in 'The Late Late Show's' signature tweets and e-mails segment, a comedy sketch and guest interviews."
"The Big Bang Theory" stars Johnny Galecki, Jim Parsons, Kaley Cuoco, Simon Helberg and Kunal Nayyar.