In the episode, Will comes to Cleveland to visit his recently transplanted mother.
Jonas is to appear in the Aug. 11 episode to be taped in front of a live studio audience Saturday.
"Hot in Cleveland," which is now in its first season, stars Bertinelli, Jane Leeves, Wendie Malick and Betty White. It was picked up July 7 for a second season of 20 episodes. The second season is to begin production in October and is expected to premiere in January 2011 on TV Land.
Jonas is one-third of the fraternal pop group Jonas Brothers.
"Cleveland" is about three women who decide to relocate to the Ohio city after realizing they are regarded as much more glamorous there than in their hometown of Los Angeles.