The May 13 show will feature appearances by "Lost" cast members including Nestor Carbonell, Michael Emerson and Jorge Garcia. Oscar-winning composer Michael Giacchino will conduct a live orchestral performance featuring the iconic music of "Lost," ABC said.
A special preview of the penultimate episode will be screened immediately after the concert.
The sixth and last season of the supernatural series is to wrap up with a 2-hour finale May 23.
Preceding the finale will be a 2-hour recap special, the network said.