The announcement was made Wednesday by Kent Alterman, the network's head of original programming and production.
The half-hour scripted series from The Onion, based on the satirical magazine's popular "Onion Sports Network" online video series, is set to premiere in early 2011.
"The Onion has such credibility in the comedy world, we feel fortunate to partner with them," Alterman said in a statement. "They will skewer the sports world, and the media coverage of sports, with the same sharpness we've seen applied to the world of politics and popular culture."
"The Onion Sports Network teaming up with Comedy Central?" added Steve Hannah, chief executive officer of The Onion. "If I were ESPN, I'd consider a whole new line of work."