Toni Collette won the prize for best actress in a comedy or musical series for her portrayal of a suburban housewife who suffers from dissociative identity disorder on Showtime's "United States of Tara."
"Gee, thank you so much. This is a real pleasure. The first time I came here 15 years ago, I was on the loo and missed my whole category," quipped the Australian actress.
John Lithgow won the award for best supporting actor in a TV series, miniseries or movie for his depiction of a serial killer on "Dexter."
"Hollywood Foreign Press Association, thank you so much for this," Lithgow said as he claimed his statuette.
Giving a nod to Showtime, the series' creative team and his co-stars, the actor added: "Thank you so much, all of you, for inviting me into the whole 'Dexter' experience. I've had the most wonderful time creeping out the entire country for the last six months."
A short while later, "Dexter" star Michael C. Hall picked up prize for best actor in a drama series.
"Thank you. Thank you to the Hollywood Foreign Press. Thank you to Showtime," Hall said. "It's really a hell of a thing to go to work at a place where everybody gives a damn and that's definitely the case with 'Dexter.' It's an amazing group from top to bottom."
The actor, who recently confirmed he is undergoing treatment for Hodgkin's lymphoma, wore a black knit cap with his suit.
Julianna Margulies won the title of best actress in a drama series for her performance in "The Good Wife."
"I just want to say thank you to (CBS executives) Les Moonves and Nina Tassler for believing in the 10 p.m. drama," Margulies said. "It's a collective effort and (the show's team) come to work with such enthusiasm. I'm blessed to go to work every day."
Alec Baldwin won the award for best actor in a comedy series for "30 Rock," Drew Barrymore took the prize for best actress in a TV movie or miniseries for "Grey Gardens" and Chloe Sevigny the trophy for best supporting actress in a TV series, miniseries or movie for "Big Love."
"Grey Gardens" won the Golden Globe for best movie or miniseries.