The Wyles are the parents of Owen, 7, and Auden, 4.
"Tracy Wyle and Noah Wyle, who separated in late October 2009, have confirmed they have entered into a mediation process," the actor's representative Eddie Michaels said in a statement issued to People.com. "Neither has legally filed for divorce. Tracy and Noah live in separate residences; however their two children see both parents daily."
Noah Wyle is best known for his work on TV's "ER." His estranged wife is a makeup artist on movie sets.