"Harry Loves Lisa" is scheduled to premiere in the fall.
The series is being executive produced by Jason Carbone and centers on the relationship between Rinna and Hamlin "as they navigate together through the highs and lows as a devoted family living a hectic Hollywood lifestyle," the network said in a news release.
"We are thrilled to be working with TV Land!" the couple, who have been married for 11 years and are the parents of two daughters, said in a statement. "Our show will shine the spotlight on the adventure that is our life and the magic that holds us together."
"There is no denying the chemistry of this amazingly beautiful, smart and sexy couple," added Larry W. Jones, president of TV Land. "When I met them, I was immediately blown away by their relationship. They are so proud and supportive of each other. It's clear why this relationship works on so many levels. Our audience will love seeing their honesty, humor and often-outrageous antics."