Danielle Mastrion is painting the mural at Wolfnights, a sandwich shop that occupies the New York City building shown on the cover of the band's second album.
At the time of the album's release, the shop was known as Lee's Sportswear.
Mastrion will begin work on the project at 11 a.m. Saturday, Rolling Stone reported.
The project was spearheaded by LeRoy McCarthy, a fan of the band who had tried to have the intersection outside the building renamed Beastie Boys Square.
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