Her first show is scheduled for April 8. Tickets are to go on sale Friday.
"I am thrilled to be able to call Las Vegas home for a while," Newton-John said in a statement. "I have performed here many times through the years and have had nothing but wonderful memories and I look forward to even more fun at the Flamingo. I am especially thrilled that a portion of every ticket sold will benefit the Olivia Newton-John Cancer and Wellness Centre."
"We look forward to welcoming Olivia to Flamingo Las Vegas, where so many other iconic artists have performed," said Eileen Moore, regional president of the resort. "She has such a broad appeal and you can count all of us here at Flamingo among her adoring fan base; she's the 'one that we want' and we can't wait for her to call Flamingo home."
Backed by an eight-piece band, Newton-John will perform some of her biggest hits, such as "Have You Never Been Mellow," "Let Me Be There," "Magic," "Twist of Fate," "If You Love Me Let Me Know," "Physical," "I Honestly Love You," "Hopelessly Devoted to You," "You're The One That I Want" and "Summer Nights."