"I'm fine. Thank u," the "Lollipop" singer, who passed Elvis Presley in September as the male with the most entries on the Billboard Hot 100 chart, wrote on Twitter Wednesday.
The performer was taken by his bodyguards to Cedars-Sinai Medical Center Tuesday night and discharged Wednesday morning following treatment, the TMZ celebrity news website reported.
Tuesday's incident was the fourth health scare since October for Wayne, born Dwayne Michael Carter Jr.
He suffered a reported seizure on his private jet bound for Los Angeles Oct. 25 and the jet made an unscheduled landing at an undisclosed Texas location. He was treated at a hospital and released.
The plane made another unscheduled landing the next day while flying from Texas to Los Angeles -- this time it stopped in Louisiana -- after Wayne suffered a second seizure and required further hospitalization.
He was reported by TMZ to have suffered several serious seizures in March and was treated at Cedars-Sinai's intensive care unit.
In a March 28 interview with radio station KPWR, Los Angeles, Wayne said he suffers from epilepsy, a chronic neurological disorder characterized by seizures.
"This isn't my first, second, third, fourth, fifth, sixth or seventh seizure. I've had a bunch of seizures," he said. "Y'all just never hear about them. But this time, it got real bad because I had three of them in a row."