Director Robert Rodriguez announced the casting and posted an image of the recording artist as her character La Chameleon on Twitter Thursday.
"I just finished working with @LadyGaga on @MacheteKills, she kicked SO MUCH ASS! Holy Smokes. Blown away!," Rodriguez said in a Twitter posting.
"Yes its true, I will be making my debut as an actress ln the amazing MACHETE KILLS BY @RODRIGUEZ IM SO EXCITED!!! AH! Filming was insane," Lady Gaga said in a separate message.
Disney's 'Jessie' to feature network's first engagement
Rosie O'Donnell unveils nearly 50-pound weight loss