Springsteen, 62, told The New Yorker magazine there is also a link between his problems and his work, noting his famously long and energetic live stage performances are fueled by "pure fear and self-loathing and self-hatred."
"Look, you cannot underestimate the fine power of self-loathing in all of this," he told the magazine. "You think: 'I don't like anything I'm seeing. I don't like anything I'm doing, but I need to change myself. I need to transform myself.' I do not know a single artist who does not run on that fuel."
The magazine said the Grammy Award-winning recording star's father suffered from depression, was possibly bipolar and frequently refused to take his meds.
"My dad was very nonverbal -- you couldn't really have a conversation with him," Springsteen said.
"My parents' struggles, it's the subject of my life," he added. "It's the thing that eats at me and always will. My life took a very different course, but my life is an anomaly. Those wounds stay with you, and you turn them into a language and a purpose."
Springsteen is married to his fellow E Street Band member Patti Scialfa. They have three children.