The hip-hop icons took home the prizes Sunday night for Best Group and Video of the Year for "The Throne."
Jay-Z's wife, Beyonce, was named Best Female R&B Artist and Chris Brown Best Male R&B Artist. Brown also picked up the AOL Fandemonium Award. Drake and Nicki Minaj won matching male and female Best Hip-Hop Artist statuettes.
"The Help" won the Best Film Award and leading lady Viola Davis the Best Actress honor.
"The Five-Year Engagement" and "Think Like a Man" star Kevin Hart won the Best Actor trophy.
Samuel L. Jackson hosted the ceremony at the Shrine Auditorium.