Spears appeared somewhat devastated at the pending sale of the 2-acre spread overlooking Conscience Bay.
"NOOOOO. I love this house!" Spears tweeted after learning fiance Jason Trawick's parents had put their vacation home up for sale for $2.5 million.
Whoever buys the home will also acquire a bit of music trivia. A source told People magazine Spears used the home as her base for the New York leg of her recent concert tour.
"She really did love staying there and it was a great getaway for peace and privacy," the source said. "Her boys loved fishing off the dock with Jason in their back yard."