The series of shows is to support "Americana," their first new album in nine years. It is to be released Tuesday.
The tour will begin Oct. 3 in Windsor, Ontario. It is expected to wrap Dec. 4 in Bridgeport, Conn.
Tickets are to go on sale in select markets beginning Friday at LiveNation.com.
Live Nation said "Americana" is "a rich collection of classic American compositions, some dating back 200 years or more and each has its own unique history veiled with multiple meanings and relatable, lyrical significance as applicable today as they were in the America of yesteryear."
The album includes classic American songs such as "Oh Susannah," "Clementine," "Get a Job," "This Land Is Your Land" and "Wayfarin' Stranger."
Crazy Horse is made up of Young, Billy Talbot, Ralph Molina and Poncho Sampredo.