The series is to debut this summer on the network.
Clarkson, Nettles, Richie and Thicke will individually set out across America looking for undiscovered talent worthy of being their proteges, a synopsis said.
"Ultimately, each superstar will choose two singers to be his/her duet partners," the synopsis said.
"Together the superstars and their proteges will take the stage each week and perform in front of a live studio audience. In the end, only one duet will be at the top of the charts, and the winning amateur will receive a recording contract with Hollywood Records."