The final show of the band's "360" tour took place Saturday night in Moncton, N.B., Canada.
The tour opened in Barcelona June 30, 2009. A total of more than 7.1 million fans have seen them perform live on stage since.
The New York Daily News said the show grossed $736.1 million.
"This tour was a brilliant success on every level and all involved should be extremely proud. U2 once again have set the standard for achievement -- perhaps for all time," Arthur Fogel, chairman of global music and chief executive officer of global touring for Live Nation, said in a statement Saturday.
"With tonight's final show, U2's 360 tour will go down as the biggest tour ever reported both in terms of box office gross and attendance," added Ray Waddell from Billboard. "This tour is a remarkable feat on a global scale, from its staging and production, to its video elements, all the way to the scaling of the house, routing and execution. Most importantly, U2 rocked mightily all over the world."