The June 19 presentation will air live on MuchMusic in Canada and Fuse in the United States.
This will be Gomez's first trip to the MMVAs.
Lady Gaga is confirmed to perform at the event. More announcements are expected to be released in the coming weeks.
"I am thrilled and honored to host the MuchMusic Video Awards," Gomez said in a statement. "I look forward to seeing all my Canadian fans and kicking off the summer together."
"Selena Gomez is a bona fide star," added Sheila Sullivan, the awards show's executive producer. "Her films and TV show ['Wizards of Waverly Place'] are seen around the world and her songs are topping the charts. Now she brings her signature smile to the MMVAs stage where her fans are guaranteed to welcome her to the most exciting and loudest award show on Earth … . Don't worry Selena, we supply earplugs."