Officials at Bonhams auction house in New York said the instruments that went on the block included his classic black Fender Stratocaster and a 1948 Gibson hollow body that alone fetched $83,000.
The BBC said Saturday the lot also included amplifiers and a Versace suit Clapton wore for a concert at a 1990 concert at London's Royal Albert Hall.
The auction was the third such benefit for the Crossroads Center, which Clapton helped establish in 1998 after he beat back his own drug and alcohol demons.
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