He is in the running for Album of the Year, Juno Fan Choice, Artist of the Year, Songwriter of the Year, Rap Recording of the Year and Single of the Year.
Up for Artist of the Year along with Drake are Reid, Bieber, Neil Young and McLachlan.
The nominees for Group of the Year are Arcade Fire, Broken Social Scene, Down With Webster, Great Big Sea and Three Days Grace.
Drake is to serve as host of the March 27 awards presentation, which is to air on CTV, the Canadian Academy of Recording Arts and Sciences said Tuesday.
Celebrity Families of 2014 [PHOTOS]