Miranda Lambert took home trophies for Female Vocalist, Album for "Revolution," produced by Frank Liddell and Mike Wrucke, and Music Video of the Year for "The House That Built Me," directed by Trey Fanjoy.
The three CMA awards were the first she has won in her career.
"'Revolution' has certainly caused a revolution in my life this year thanks to the country music industry," Lambert said after winning the album award. "It's what I love, it's what I do, it's what I live for, so thank you for loving it, too."
After winning the evening's top prize, an emotional Paisley quoted his hero Little Jimmy Dickens: "'If you see a turtle on a fence post it had help getting there.' I feel just like a turtle on a fence post right now...
"It sounds like a cliche when you say thanks to the fans, but the great thing about country fans is that when you say 'fans,' I don't even mean mine. You guys are loyal to everyone in this room," Paisley added.
The 44th annual CMA Awards was presided over for the third time by Paisley and Carrie Underwood, and broadcast live from the Bridgestone Arena in Nashville on the ABC Television Network.
Blake Shelton was named Male Vocalist of the Year and Zac Brown Band was declared New Artist of the Year.
Lady Antebellum picked up the gong for Vocal Group of the Year and the producers of their song "Need You Now" won the Single of the Year honor.
Sugarland went home with the statuette for Vocal Duo of the Year.
"The House That Built Me" won the Song of the Year award for songwriters Tom Douglas and Allen Shamblin.