The clip premiered on AOL Music's Spinner.com Monday.
The track is from Guy's upcoming 11th Silvertone/Jive studio album, "Living Proof," which is set for release Oct. 26.
The song marks the first time the two blues icons have performed and sung together on a studio release, the record label said.
Costly malfunction causes beer flood at Boston-area brewery
Megyn Kelly: Santa Claus and Jesus are both white men